Michelle (Emma Stone), an influential director of a large pharmaceutical company, has a justified feeling that the world is at her feet. Unfortunately, this lasts only until she wakes up on a dirty mattress in a strange basement, handcuffed, with her head shaved and body covered in a strange cream. She has been kidnapped by two cousins, Teddy (Jesse Plemons) and Don (Aidan Delbis), who are firmly convinced that Michelle comes from another planet and has been tasked with destroying all intelligent life on Earth. Michelle realises that it's no use resisting these lunatics, so she tries every corporate tactic and trick she can think of to get out of the situation unscathed. Who is more dangerous? Two crazy guys who will do anything to save their fellow human beings, or a ruthless predator of the corporate world?